Ryan Tannehill threw three touchdown passes and Derrick Henry ran for 113 yards as the Tennessee Titans pulled out a 25-16 victory over the Indianapolis Colts in Nashville, Tenn.

Tannehill hit Jeremy McNichols for a 10-yard scoring strike with 12:56 left in the game, followed by a two-point conversion run by Henry that gave Tennessee (2-1) a 22-13 lead.

After Rodrigo Blankenship made his third field goal for the Colts (0-3), a 24-yarder with 10:20 left, the Titans melted nearly 7 1/2 minutes off the clock before Randy Bullock converted the game-sealing 32-yard field goal with 2:58 remaining.

Tannehill completed 18 of 27 passes for Tennessee, which possessed the ball for just over 34 minutes and outgained Indianapolis 368-265.

Carson Wentz hit on 19 of 37 passes for 194 yards for Indianapolis while playing on two sprained ankles. Jonathan Taylor managed 64 yards on 10 carries, but the Colts' running game was hampered by the loss of guard Quenton Nelson in the second quarter with an injury.

Tennessee got off to a fast start, scoring on its first drive when Tannehill found Chester Rogers for a 6-yard touchdown pass that capped an 11-play drive that lasted more than 5 1/2 minutes.

Indianapolis used the first of two Tannehill interceptions as a vehicle to its first score. Nine plays after Darius Leonard picked off Tannehill to stop a promising drive, Nyheim Hines zipped 9 yards around left end with 10:19 left in the first half to tie the game.

The Titans responded when Tannehill and Nick Westbrook-Ikhine connected on an 18-yard scoring strike with 5:56 remaining for a 14-7 lead. For Westbrook-Ikhine, it was his first NFL touchdown.

Tennessee was driving again later in the half when a second Tannehill interception was returned 32 yards by Kenny Moore. Blankenship's 43-yard field goal as time expired pulled the Colts within 14-10 at intermission.

Henry carried the football 28 times and added three catches for 31 yards.

--Field Level Media