Maurice Jones-Drew rushed for 114 yards and a touchdown as the visiting Jacksonville Jaguars kept the Indianapolis Colts winless with a 17-3 victory Sunday.

Two interceptions by Colts quarterback Curtis Painter and a crucial fumble by his replacement, Dan Orlovsky, late in the fourth quarter sent Indianapolis to its 10th consecutive defeat.

Orlovsky was sacked attempting to make a pass and the ball was grabbed out of the air by Jaguars tackle Tyson Alualu deep in Indianapolis territory.

Jones-Drew scored three plays later from 3 yards out to put the game away as Jacksonville (3-6) ended its six-game road losing streak.

Rookie Blaine Gabbert capped a near 10-minute drive in the third quarter with an 11-yard touchdown pass to Jarrett Dillard to give the Jaguars 10-3 lead.

Jones-Drew had 78 yards rushing by halftime but the game was tied at 3-3 as both teams managed little offensively. Josh Scobee booted a 44-yard field goal to give the Jags a 3-0 lead in the first quarter.

Indy's Adam Vinatieri responded with a 42-yard field goal early in the second quarter.