NORMAN, Okla. -- Oklahoma got a huge game from Baker Mayfield.

The No. 16 Sooners needed almost every bit of it, finally escaping with a 52-38 win over Tulsa at Gaylord Family-Oklahoma Memorial Stadium on Saturday.

Mayfield set a school record with 572 yards of total offense, including 487 passing, and accounted for six touchdowns.

"Baker Mayfield was sensational -- running, passing, keeping plays alive," Sooners coach Bob Stoops said.

No play showed all three of things better than his final touchdown pass of the day in the last minute of the third quarter.

With Oklahoma clinging to a seven-point lead, Mayfield escaped between two Tulsa defenders, looked to scramble before taking a few steps backward away from Tulsa defender Matt Linscott and finding Mark Andrews open for a 17-yard touchdown pass.

"It's just a little scramble drill," Mayfield said. "I know the O-line would like to have that one back. We whiffed out but I just made things work.

"Mark was working all the way across the field. He did a good job of coming open, I saw him and just gave him a nice ball."

The touchdown was one of two for Andrews, who also caught a 61-yard touchdown pass from Mayfield.

"Mark is a matchup nightmare," Sooners' receiver Sterling Shepard said.

The scores were the first of Andrews' career.

Offensive coordinator Lincoln Riley was pleased with Mayfield's play -- he has thrown 10 touchdown passes and two interceptions in Oklahoma's 3-0 start -- but said there was plenty of improvement that remained to be had for the Texas Tech transfer.

"In these deals, you're tempted to look at the stats and the stats would say you're probably not going to do a whole lot better than that but there's still a lot of things that he can do better, a lot of things that we can do better as an offense," Riley said.

"The stats don't always tell the whole story. There'll be times hopefully throughout his career and maybe for us offensively where we play better and maybe you don't have numbers like this."

While Oklahoma's offense soared, its defense suffered at times under the attack of Philip Montgomery's Air Raid offense.

Tulsa quarterback Dane Evans passed for 427 yards and four touchdowns as the Golden Hurricane (2-1) tested the Sooners repeatedly down the field.

"They changed some things up defensively, so we had to make some adjustments there in the first quarter," Montgomery, Tulsa’s first-year coach, said. "We got a better feel for what was going on ands those guys stepped up big and made some plays."

The Sooners seemed poised to blow the game open in the final two minutes before half, leading 31-10 and with the ball just outside the Tulsa 20.

Things turned around quickly, though, beginning with Joe Mixon's fumble one play after Shepard's 44-yard catch.

The Golden Hurricane quickly moved the ball downfield, finishing off the drive on a 28-yard touchdown pas from Evans to Keevan Lucas with 13 seconds remaining before half.

Tulsa's ensuing kick bounced high into the air off Oklahoma's Frank Shannon before being recovered by the Golden Hurricane at the Sooners 43.

Evans found receiver Keyarris Garrett in the end zone on a Hail Mary pass one play later to turn what looked like a blowout into a seven-point game at halftime, 31-24.

Garrett finished with 14 catches for 189 yards and a touchdown. Lucas had five catches for 84 yards and two score.

Shepard finished with eight catches for 144 yards.

Tulsa running back Zack Langer rushed for 161 yards and a touchdown.

Before last week when Tennessee's Jalen Hurd topped the mark, Oklahoma had not allowed a 100-yard rusher since a 45-31 loss to Alabama in the Sugar Bowl following the 2013 season.

NOTES: The previous school record for total offense for Oklahoma was 554 by QB Landry Jones against West Virginia in 2012. ... Oklahoma RB Samaje Perine left the game late in the first half after sustaining a hand injury on a fumble. Perine returned in the second half. ... Tulsa CB Darrell Williams sustained an apparent leg injury early in the game and did not return. ... Sooners LB Devante Bond blocked Redford Jones' 32-yard field goal try on the first play of the second quarter. The ball was recovered at midfield by Ahmad Thomas. ... Oklahoma C Ty Darlington missed the game because of a knee injury sustained a week earlier at Tennessee. Jonathan Alvarez shifted from guard to start in Darlington's spot and Derek Farniok started at Alvarez's guard spot. ... Freshman CB P.J. Mbanasor made his second start of the season in place of Jordan Thomas, who did not play for disciplinary reasons. ... Tulsa DE Derrick Alexander and Oklahoma LB Dominique Alexander are brothers. Both started Saturday's game and Derrick Alexander recovered a fumble in the second quarter. ... Oklahoma has a week off before opening Big 12 play at home against West Virginia on Oct. 3. Tulsa also has a week off before opening American Athletic Conference play at home against Houston.