OAKLAND, Calif. -- Not long after hitting a two-run homer in the first inning Saturday against the Washington Nationals, Oakland Athletics third baseman Ryon Healy let teammate Trevor Plouffe in on a secret.

"It's funny," Healy recalled. "I said to Plouffe, 'I've never had a two-homer game in pro ball.' He goes, 'Well, today's a pretty good day to do so.'"

Indeed it was.

Healy went 4-for-4 with two home runs and two doubles, powering Oakland to a 10-4 victory against the Nationals at the Oakland Coliseum.

Healy hit a solo blast in the seventh to go with his two-run shot in the first. He tied the Athletics' franchise record of four extra-base hits in a game, a feat that hadn't been accomplished since July 20, 2009 by Matt Holliday against Minnesota. The four hits and two home runs were career highs for Healy, who has 11 homers this season.

"Big day for him," A's manager Bob Melvin said. "We've seen him do that. Not only does he have power, but he has power to all fields and he can make adjustments."

One day after losing 13-3 to Washington and right-hander Stephen Strasburg in the opener of the three-game series, the A's got even.

The A's had a two-run homer in the first inning from Jed Lowrie, who went 3-for-5 with two doubles and a career-high tying four RBIs. Yonder Alonso hit a two-run homer in the seventh, extending his career high to 16 on the season. Then there was Healy, who had four extra base hits in a game for the first time in his life.

"It's just kind of a blur," Healy said. "You're focusing on the right things, getting good pitches to hit and most importantly not missing them. It's really tough to hit on this level when you're missing good pitches. I did that yesterday against Strasburg."

Washington's Adam Lind went 2-for-3 with a double and a three-run homer, his fourth blast of the season. Daniel Murphy had three hits, including a double, for the Nationals.

Bryce Harper served the third and final game of his suspension for fighting San Francisco Giants reliever Hunter Strickland on Monday after being hit by a pitch.

A's right-hander Daniel Mengden allowed four runs on six hits over 4 2/3 innings and received a no-decision in his second start of the season.

After Mengden exited, Liam Hendriks (2-0), Daniel Coulombe, Ryan Madson and John Axford combined to blank Washington over the final 4 1/3 innings.

Nationals right-hander Joe Ross, who grew up in Oakland, had a rough homecoming in his first career appearance against the A's. Ross (2-2) allowed seven runs (six earned) on six hits over three innings.

"I was trying to be a bit too fine," Ross said. "I was throwing around the zone and then I had to come in and they hit it."

The A's grabbed a 4-0 lead in the first inning. After shortstop Chad Pinder reached base with one out on catcher's interference, Lowrie launched Ross' 3-2 sinker into the right field seats for his seventh blast of the season.

Alonso singled with two outs, and Healy followed with a two-run shot to right-center off Ross.

"It seemed like Joe was fighting Joe," Nationals manager Dusty Baker said. "I know how bad he wanted to pitch well here in Oakland. You have to go back to concentration, confidence, relaxation."

Washington cut Oakland's lead to 4-1 in the second when Lind doubled, moved to third on a wild pitch and scored on Stephen Drew's sacrifice fly.

Oakland responded with two runs in the bottom half to make it 6-1. Josh Phegley singled, Matt Joyce walked, and Lowrie lined a two-run double into the right-field corner.

"He's been swinging a hot bat all year," Melvin said of Lowrie. "He's probably been the most consistent bat for us, and that's why he's hitting in the three-spot."

The Nationals sliced Oakland's lead to 6-4 in the third. Murphy blooped a single to left with two outs when Pinder appeared to lose the ball in the sun. Ryan Zimmerman walked, and Lind sent Mengden's 2-2 curve into the right field seats for a three-run homer.

The A's scored a run in the third and added three in the seventh when Khris Davis lined a leadoff single and Alonso and Healy hit back-to-back homers.

NOTES: Nationals DH Jayson Werth fouled a pitch off his left foot in the ninth inning. He left the game for a pinch runner after reaching base on an error. "I think it's going to be all right," Werth said. ... Nationals OF Chris Heisey (right biceps rupture) will resume baseball activities after trainers "get some swelling out of his arm," manager Dusty Baker said. Heisey began a minor league rehab assignment Monday but was shut down after a setback. Baker said team doctors still don't believe Heisey will need surgery. ... A's RHP Jesse Hahn (right triceps strain) threw his regular bullpen session Saturday with no issues and said he's on track to come off the disabled list and rejoin the rotation next week, once he gets the OK from manager Bob Melvin. ... A's LHP Sean Doolittle (strained left shoulder) will make his second rehab appearance Sunday or Monday for Class A Stockton.