Catcher Matt Wieters drove a two-out, two-run homer 390 feet onto the top balcony of the Western Metal Supply Co. building in left field at Petco Park in the 11th inning Sunday afternoon, giving the visiting St. Louis Cardinals a 5-3 win over the Padres.

Wieters' fourth homer of the season followed a two-out single rolled by Kolten Wong to Padres first baseman Eric Hosmer. Wieters connected on a 1-2 slider from left-handed reliever Brad Wieck (0-1).

Right-hander Carlos Martinez (2-0) allowed a hit and a walk with four strikeouts over 2 2/3 innings of scoreless relief to get the win. Dominic Leone picked up his first save.

The Padres built a 3-0 lead in the first five innings against Cardinals starter Miles Mikolas on a two-run homer by Manny Machado and the speed of rookie shortstop Fernando Tatis Jr.

Machado's home run followed a one-out, opposite-field double by Hosmer in the first. The home run was Machado's 10th in the last 15 games and his 20th of the season -- giving the Padres three players with 20 homers before the All-Star break for the first time in franchise history.

Tatis singled with two out in the fifth and scored from first on Hosmer's single to right-center. Tatis raced home ahead of the relay from right fielder Jose Martinez through second baseman Tommy Edman to score his 26th run in the last 20 games.

But the Cardinals tied the game with two runs in the sixth and an unearned run in the top of the eighth.

St. Louis loaded the bases in the sixth on a pair of walks around a single by Paul DeJong against Padres starter Joey Lucchesi. Martinez and DeJong scored on Yairo Munoz's two-out single off reliever Luis Perdomo.

Paul Goldschmidt topped a infield single to third with one out in the eighth against Craig Stammen and moved to second on Machado's throwing error. With one out, Tyler O'Neill singled to right. Goldschmidt initially stopped at third, then scored when Franmil Reyes bobbled the ball.

Lucchesi allowed two runs on four hits and three walks with six strikeouts in 5 1/3 innings. Mikolas gave up three runs on eight hits and no walks with four strikeouts in six innings. Each starter threw 87 pitches.

--Field Level Media