Domingo Santana, Tom Murphy and Edwin Encarnacion hit homers in a seven-run sixth inning as the Seattle Mariners defeated the visiting Houston Astros 14-1 Wednesday night to snap a four-game losing streak.

Right-hander Mike Leake (5-6) pitched Seattle's first complete game of the season, allowing six hits with two walks and five strikeouts.

Pinch-hitter Mac Williamson, making his Seattle debut, added a three-run homer, and Kyle Seager had a solo shot, both in the eighth, as the Mariners ended Houston's five-game winning streak and beat the Astros for the first time in six tries this season.

Astros right-hander Brad Peacock (5-3) allowed only one hit through four scoreless innings before running into trouble in the fifth.

With the Mariners trailing 1-0, Seager led off with a walk and Santana grounded a single to center. Shed Long then lined a single to right, with Seager held at third to load the bases with no outs.

It appeared Peacock might get out of the jam when he struck out Murphy and got Dylan Moore to hit a chopper to third, with Alex Bregman forcing out Seager at the plate. But Mallex Smith lined the next pitch into right field for a two-run single to give the Mariners the lead.

Peacock (5-3) went five innings, allowing two runs on four hits. He walked two and struck out six.

The Mariners teed off on Astros relievers Reymin Guduan and Brady Rodgers in the sixth.

Daniel Vogelbach led off with a walk and, an out later, Santana hit a two-run homer to right-center field. After Long grounded a single to center, Rodgers replaced Guduan, and Murphy hit Rodgers' first pitch over the left-field wall to give the Mariners a 6-1 lead.

Moore and Smith singled and, with two outs, Encarnacion hit a three-run blast into the second deck in left field. It was Encarnacion's team-leading 17th homer of the season and the 397th of his 15-year career.

The Mariners capped the scoring with a five-run eighth. Astros first baseman Tyler White pitched the final two-thirds of an inning, allowing Seager's home run.

The Astros scored their lone run in the first.

With one out, Bregman lined a single to center, Michael Brantley walked and Josh Reddick grounded a single to left to load the bases. Bregman scored on White's sacrifice fly to center.

--Field Level Media